Table 1.
Sample Characteristics.
| Variable | ROS | MAP | Combined |
|---|---|---|---|
|
| |||
| Total N | 392 | 199 | 591 |
|
| |||
| Age at Death | |||
| Mean (SD, range) | 86.3 (7.0, 66-104) | 88.0 (5.8, 66-102) | 86.9 (6.7, 66-104) |
|
| |||
| Education (years completed) |
|||
| Mean (SD, range) | 18.0 (3.5, 3-30) | 14.7 (2.9, 6-22) | 16.9 (3.7, 3-30) |
|
| |||
| Gender | |||
| N (%) Female | 233 F (59.4%) | 115 F (57.8%) | 348 F (59%) |
| N (%) Male | 159 M (40.6%) | 84 M (42.2%) | 243 M (41%) |
|
| |||
| Race | |||
| N (%) Caucasian | 377 C (96.2%) | 192 C (96.5%) | 569 C (96.3%) |
| N (%) African American | 13 AA (3.6%) | 7 AA (3.5%) | 20 AA (3.4%) |
| N (%) Hispanic | 2 H (0.1%) | 2 H (0.3%) | |
|
| |||
| APOE Status | |||
| N (%) ε4 negative | 275 ε4− (70.9%) | 134 ε4− (69.8%) | 409 ε4− (70.5%) |
| N (%)ε 4 positive | 113 ε4+ (29.1%) | 58 ε4+ (30.2%) | 171 ε4+ (29.5%) |
|
| |||
| Clinical Diagnosis, Last | |||
| Evaluation | |||
| N (%) Normal | 125 N (31.9%) | 66 N (33.2%) | 191 N (32.3%) |
| N (%) MCI | 89 M (22.7%) | 57 M (28.6%) | 146 M (24.7%) |
| N (%) Dementia | 178 D (45.4%) | 76 D (38.2%) | 254 D (43.0%) |
|
| |||
| Neuritic Plaque Counts (mean, range) |
|||
| mid-frontal | 9.7 (0 – 81) | 8.5 (0 – 48) | 9.3 (0 – 81) |
| mid-temporal | 9.7 (0 – 93) | 8.8 (0 – 64) | 9.4 (0 – 93) |
| inferior parietal | 9.6 (0 – 67) | 10.3 (0 – 55) | 9.8 (0 – 67) |
| hippocampal | 4.3 (0 – 46) | 4.4 (0 – 34) | 4.3 (0 – 46) |
| entorhinal | 8.1 (0 – 50) | 9.2 (0 – 58) | 8.4 (0 – 58) |
|
| |||
| Diffuse Plaque Counts (mean, range) |
|||
| mid-frontal | 18.5 (0 – 193) | 17.6 (0 – 121) | 18.4 (0 – 193) |
| mid-temporal | 17.6 (0 – 147) | 14.6 (0 – 89) | 16.6 (0 – 147) |
| inferior parietal | 15.1 (0 – 139) | 15.4 (0 – 108) | 15.2 (0 – 139) |
| hippocampal | 2.1 (0 – 29) | 2.3 (0 – 27) | 2.2 (0 – 29) |
| entorhinal | 7.3 (0 – 69) | 7.9 (0 – 57) | 7.5 (0 – 69) |
|
| |||
| Neurofibrillary Tangle Counts (mean, range) |
|||
| mid-frontal | 1.3 (0 – 32) | 1.3 (0 – 65) | 1.3 (0 – 65) |
| mid-temporal | 4.6 (0 – 66) | 4.6 (0 – 72) | 4.6 (0 – 72) |
| inferior parietal | 1.9 (0 – 48) | 2.0 (0 – 54) | 2.0 (0 – 54) |
| hippocampal | 19.9 (0 – 154) | 24.9 (0 – 134) | 21.8 (0 – 154) |
| entorhinal | 21.0 (0 – 130) | 24.1 (0 – 100) | 22.1 (0 – 130) |