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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: Cancer Res. 2014 Jan 30;74(6):1870–1880. doi: 10.1158/0008-5472.CAN-13-2485

Figure 2.

Figure 2

P300 knockout decreases cell proliferation and AR protein levels in PTEN-deleted prostate tumors in mice. A, IHC for Ki-67 in the prostates of 4-month-old mice with indicated genotypes (n = 3/group). The inset in each panel shows a representative (framed) area in high magnification. Scar bar, 50 μm. Scare bar in inset, 10 μm. B, quantitative data of Ki-67 staining shown in (A). Columns, mean values of Ki-67 positive cells among three individual mice. Error bars, SD. *, p < 0.01. C, IHC of AR protein in the prostates of 4-month-old mice with indicated genotypes (n = 3/group). Scar bar, 50 μm. D, western blot analysis of indicated proteins in cell lysates prepared from the prostates of three mice in each group at 4 months of age.