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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: J Immunol. 2014 Jan 31;192(5):2156–2166. doi: 10.4049/jimmunol.1300675

Figure 4. STAT1, but not STAT3 or STAT4 is required for type I IFN mediated induction of key TFH cell molecules.

Figure 4

(A, B) p-STAT3, p-STAT4, and p-STAT1 staining in CD4+ T cells cultured in the presence of the indicated cytokines without TCR stimulation for 30 minutes. Graphs (means ± SD) are from duplicate cultures and are representative of three independent experiments. (C-E) Bcl6 and T-bet (C), IL-21 and IFN-γ (D), or CXCR5 and PD-1 (E) staining in CD4+ T cells cultured in the presence of the indicated cytokines for 5 days from WT, Stat1−/−, Stat3−/−, or Stat4−/− mice. Data (mean ± SD) are from duplicate cultures of three independent experiments (n=6). The plots are representative of three independent experiments. *, p<0.05; **, p<0.01.