Table 2. Enrichment for cancer breakpoint hotspots in genomic blocks with over-representation of G4 sequences and hypomethylation.
| Total no. genomic blocks | SCNA breakpoint hotspots (A) | Genomic blocks with: | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| PG4s density | Differential methylation | No. blocks (B) | Overlap between groups A and B | Corresponding P value | ||
| 3,029 | 248 | > mean | < mean | 579 | 72 | 2.47 × 10−5 |
| 3,029 | 248 | > mean + s.d. | < mean | 205 | 30 | 5.09 × 10−4 |
| 3,029 | 248 | > mean | < mean − s.d. | 272 | 39 | 1.26 × 10−4 |
| 3,029 | 248 | > mean + s.d. | < mean − s.d. | 122 | 22 | 1.69 × 10−4 |