Table 1.
Genomic organization of the human caveolin genes and properties of their protein products
| Human gene | Chromosomal location | Exon | Exon size (bp) | Intron | Intron size (kb) | Residues encoded by exon | Length of protein (amino acids) | Percentage similarity (identity) to human Cav-1 | Percentage similarity (identity) to human Cav-2 | Expression patterns |
| Cav-1 | 7q31.1 | 1 | 30 | 1 2 3 |
1.47 31.8 |
1-10 11-65 66-178 |
178 |
- |
59 (40) |
Ubiquitous; highest levels in adipocytes, endothelia, smooth muscle cells, and Type I pneumocytes |
| Cav-2 | 7q31.1 | 1 2a 2b |
150 188 151 |
1 2 |
0.33 5.76 |
1-50 51-112 113-162 |
162 |
58 (38) |
- |
Co-expressed with Cav-1 |
| Cav-3 | 3p25 | 1 2 |
114 342 |
1 |
? |
1-38 39-151 |
151 |
85 (65) |
60 (39) |
Muscle-specific; primarily in skeletal and cardiac myocytes |
Abbreviations: bp, base pairs; kb, kilobases; ?, unknown. Modified from Razani et al. [42].