Skip to main content
. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Nat Methods. 2013 Sep 22;10(11):1085–1088. doi: 10.1038/nmeth.2640

Figure 3. DD-Cre/TeNT mice exhibit a TMP-dependent loss of recognition and spatial memory.

Figure 3

Mice of indicated genotypes were tested for locomotor activity and memory acquisition/retrieval. Animals were treated once with either vehicle or TMP (170 μg/gm) 48 hours prior to initiation of behavioral trials.

a, Total horizontal locomotor acivity was assessed with photocell beams for 2 hours over 5 min time intervals.

b and c, Novel object recognition and spatial memory tests. b, Averaged numbers of contacts initiated by each group of mice with old (O) and novel (N) objects (O versus N: TeNT+Vehicle, P = 0.035; TeNT+TMP, P = 0.038; DD-Cre/TeNT+Vehicle, P = 0.007; DD-Cre/TeNT+TMP, P = 0.94). c, Averaged percentages of time spent in correct target (T) and other (O) quadrants in the Barnes maze probe test (DD-Cre/TeNT+TMP versus DD-Cre/TeNT+Vehicle, P = 0.026; DD-Cre/TeNT+TMP versus TeNT+TMP, P = 0.019; DD-Cre/TeNT+TMP versus TeNT+Vehicle, P = 0.024; DD-Cre/TeNT+Vehicle versus TeNT+TMP, P = 0.9; DD-Cre/TeNT+Vehicle versus TeNT+Vehicle, P = 0.98; TeNT+TMP versus TeNT+Vehicle, P = 0.92). All measurements were performed with P60 animals (n = 7–9 mice per group) and represented as Mean±S.E.M. See also Supplementary Fig. 9 and Table 3 for additional behavioral data.