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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: Nat Rev Immunol. 2011 Oct 10;11(11):762–774. doi: 10.1038/nri3070

Figure 3. Pro-inflammatory cytokines and TLR ligands promote the emigration of LY6Chi monocytes from the bone marrow.

Figure 3

Monocyte emigration from the bone marrow during the early stage of infection with Listeria monocytogenes is normal in mice that lack either myeloid differentiation primary response protein 88 (MYD88; which is required for most responses to Toll-like receptor (TLR) ligands) or the type I interferon receptor (IFNAR). However, the combined loss of MYD88 and IFNAR impairs monocyte emigration from the bone marrow. IFN, interferon.