Figure 2.
FR4 expression on naive precursors does not determine TFH/TH1 commitment. Differentiation of FR4hi and FR4lo cells isolated from naive mouse spleen was determined as shown in (A). In (B), frequency and expression of FR4 on donor cells is shown in recipient spleen at day 8 post-infection. Bar graphs in (C) show number and frequency of donor cells per spleen. (D), shows % of TFH identified by co-expression of CXCR5 and PD-1, and CXCR5 and FR4 and % of GL7+ GC TFH in spleen at day 8 post-infection. Data are representative of three independent experiments. Bar graphs show mean ± SEM