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. Author manuscript; available in PMC: 2015 Feb 21.
Published in final edited form as: ACS Chem Biol. 2013 Nov 20;9(2):353–358. doi: 10.1021/cb400660a

Figure 2. Synthesis of tivantinib enantiomers and analogues.

Figure 2

(A) Synthetic strategy and chemical structures of (−)-tivantinib (8), its enantiomer (+)-tivantinib (7) and their coupleable analogues, (9) and (10), respectively. For the full synthetic route see Figure S1A. (B) Differential inhibition of cellular viability of A549 and H1648 cells by (−)-tivantinib and (+)-tivantinib.