Table 5. Adjusted HR estimates for SphK1 expression and recurrence of colon cancer-specific using multivariate Cox regression analysis.
|
Multivariate analysis |
|||
|---|---|---|---|
| Variables | Adjusted SHR | 95% CI | P value |
| SphK1 expression | |||
| Absence (Ref) | 1.0 | — | — |
| Presence | 1.35 | 0.48–3.77 | 0.564 |
| Age | |||
| ≤65 years (Ref) | 1.0 | — | — |
| >65 years | 1.33 | 0.73–2.42 | 0.344 |
| Ethnicity | |||
| Chinese (Ref) | 1.0 | — | — |
| Malays | 3.29 | 1.35–8.02 | 0.009 |
| Indians | 2.17 | 0.45–10.50 | 0.336 |
| Others | 0.86 | 0.14–5.23 | 0.873 |
| Pre-op CEA levels | 1.002 | 1.00–1.001 | 0.647 |
| AJCC stage | |||
| Stages 1 and 2 (Ref) | 1.0 | — | — |
| Stages 3 and 4 | 2.28 | 1.22–4.29 | 0.01 |
| Vascular invasion | |||
| Absence (Ref) | 1.0 | — | — |
| Presence | 1.52 | 0.55–4.23 | 0.422 |
CEA, carcinoembryonic antigen; CI, confidence interval; HR, hazard ratio; SHR, sub-hazard ratio; SphK1, sphingosine kinase 1.