Table 3.
Univariate Fisher exact test (p-values) to show significant differences between mutation profiles of each endometrial carcinoma subtypes.
| Low-Grade Endometrioid vs High-Grade Endometrioid | Low-Grade Endometrioid vs Serous | High-Grade Endometrioid vs Serous | High-Grade Endometrioid vs Carcinosarcoma | Serous vs Carcinosarcoma | |
|---|---|---|---|---|---|
| PTEN | 0.0111 | 6.58E-15 | 2.57E-14 | 1.09E-06 | 4.30E-04 |
| PIK3CA | 0.0522 | 0.2091 | 0.0235 | 0.0276 | 1.0000 |
| ARID1A | 0.1826 | 1.38E-05 | 2.42E-05 | 0.0030 | 0.1522 |
| KRAS | 0.2000 | 0.2328 | 0.0525 | 0.3814 | 0.3215 |
| CTNNB1 | 0.8211 | 1.23E-03 | 0.0394 | 0.0602 | 1.0000 |
| PPP2R1A | 0.4630 | 4.96E-08 | 2.95E-03 | 0.3365 | 0.0526 |
| TP53 | 4.62E-03 | 8.56E-14 | 3.17E-03 | 0.0080 | 0.8151 |
| BRAF | 0.2555 | 0.3352 | 1.0000 | 0.5669 | 0.5972 |
| PPP2R5C | 0.0263 | 1.0000 | 0.1967 | 0.1702 | NA |
Bold indicates significant p-values <0.05