Table 2.
IFN-γ in human systemic autoimmune diseases
| Disease | IFN-γ Phenotype | Reference |
|---|---|---|
| SLE | Increased IFN-γ mRNA in PBMC. | Csiszár et al, 2000 |
| Increased IFN-γ in serum of patients with active disease. | Funauchi et al, 1991 | |
| Increased IFN-γ RNA and protein after anti-CD3/CD28 stimulation of PBMC. | Harigai et al, 2008 | |
| Increased IFN-γ mRNA in PBMC correlated with T-bet mRNA. IFN-γ/IL-4 ratio correlated with disease activity. | Lit et al, 2007 | |
| Increased IFN-γ/IL-4 ratio by intracellular flow cytometry in PBMC of patients with diffuse proliferative glomerulonephritis. | Akahoshi et al, 1999 | |
| Increased IFN-γ/IL-4 ratio in PBMC and increased IFN-γ+ cells in renal biopsy of patients with diffuse proliferative glomerulonephritis . | Masutani et al, 2001 | |
| SS | Increased IFN-γ secretion of PBMC from SS patients with Raynaud’s phenomenon stimulated with T cell mitogen phytohemagglutinin. | Willeke et al, 2009 |
| Prominent IFN-γ transcriptional response in SS salivary glands. | Hall et al, 2012 | |
| DM | Increased IFN-γ mRNA in skin of DM patients correlates with IFN transcriptional response in DM skin | Wong et al, 2012 |
| SSc | Increased IFN-γ by intracellular flow cytometry in T cells of patients with limited SSc. Increased in vitro IFN-γ secretion by T cells of patients with limited SSc. | Radstake et al, 2009 |