Figure 7. Activation of NFATc1 negates the protective effects of IRF8 on cardiac hypertrophy in IRF8-TG mice.
(a) Histological analyses of the HE and PSR staining of the indicated groups at 4 weeks after AB surgery (n=5–7 mice per experimental group; scale bar, 100 μm for upper HE staining, scale bar, 20 μm for lower HE staining, scale bar, 50 μm for PSR staining). (b–f) Statistical results for the ratios of (b) cell sectional area (n≥100 cells per experimental group); (c) LV collagen volume (n≥25 fields per experimental group); (d) HW/BW; (e) LW/BW; and (f) HW/TL (n=11 mice per experimental group) in the indicated groups at 4 weeks after AB surgery. The data represent as the mean±s.d. Statistical analysis was carried out by two-way analysis of variance with general linear model procedures using a univariate approach.