Table 3.
Univariate effects of selected variables on age of presentation of pancreatic cancer
| Variable | Median age |
95% CI | Log-rank P-value |
|---|---|---|---|
| Center | 0.0611 | ||
| Italy | 65.3 | 62.9–68.3 | |
| US centers | 67.8 | 66.7–68.9 | |
| Gender | 0.0193 | ||
| Male | 66.6 | 65.7–68.4 | |
| Female | 68.2 | 67.1–69.8 | |
| BMI | 0.0463 | ||
| Normal weight (BMI<25) | 69.6 | 68.0–71.5 | |
| Overweight (25≤BMI≤30) | 67.3 | 65.5–68.9 | |
| Obese (BMI>30) | 66.3 | 64.5–68.0 | |
| Race | 0.2648 | ||
| White | 67.7 | 66.6–68.5 | |
| Other | 65.9 | 57.6–68.2 | |
| Diabetes status | 0.5173 | ||
| Established diabetes (>2 years) | 69.5 | 66.6–71.4 | |
| Recent Dx (≤2 years) Unknown Dx date | 69.3 | 66.3–70.8 | |
| Unknown Dx date | 72.5 | 63.8–76.6 | |
| No known Hx diabetes | 66.6 | 65.6–67.8 | |
| Family Hx pancreas Ca | 0.0216 | ||
| No | 67.7 | 66.6–68.6 | |
| Yes | 65.6 | 58.8–69.8 | |
| Smoking status | <0.0001 | ||
| Nonsmokers | 69.5 | 67.7–71.2 | |
| Past smokers (quit > 10 years ago) | 70.0 | 67.6–72.2 | |
| Past smokers (quit ≤10 years go) | 61.8 | 58.3–65.5 | |
| Active smokers | 61.6 | 59.0–63.4 | |
| Cigarette (PPD) | 0.0002 | ||
| Nonsmokers | 69.5 | 67.7–71.2 | |
| 0 <PPD≤1 | 66.5 | 64.7–67.5 | |
| PPD >1 | 63.8 | 61.8–66.9 | |
| Alcohol status | 0.0015 | ||
| Nondrinker | 70.2 | 68.4–71.8 | |
| Quit > 10 years before Dx | 66.4 | 62.7–69.1 | |
| Quit 1–10 years before Dx | 66.5 | 55.9–72.3 | |
| Active drinker | 65.9 | 64.3–67.6 | |
| Alcohol amount/day | <0.0001 | ||
| Nondrinker | 70.2 | 68.4–71.8 | |
| <13g | 67.4 | 65.7–69.1 | |
| 13–39g | 66.1 | 62.9–69.0 | |
| >39g | 61.4 | 58.0–64.3 | |
| Types of alcohol used | 0.0024 | ||
| Nondrinker | 70.2 | 68.4–71.8 | |
| Beer | 64.9 | 62.4–68.4 | |
| Red wine White wine | 68.4 | 64.9–71.7 | |
| White wine | 66.8 | 62.1–72.2 | |
| Hard liquor | 68.4 | 64.7–73.7 | |
| Multiple types | 65.5 | 62.7–66.6 | |
| Entire cohort | 66.3 | 64.5–68.0 |
BMI, body mass index; CI, confidence interval; Dx, diagnosis; Hx, history of; PPD, packs per day.