Fig. 1.

Acquisition (A), extinction (B) and reinstatement (C) of CPP in methamphetamine dependent rats assigned to ceftriaxone vs. saline groups (Ceftriaxone group recived ceftriaxone 200 mg/kg IP only during the extinction phase of the study). Time spent in methamphatmine-paired chamber during reinstatement (n=8) (mean±SEM): 12.83±0.74 vs. 4.14±0.5 two-tailed independent t-test=27.5, df=14, p<0.001.