Figure 5. Enhancement, by anti-OX40, of the immune response to reporter antigens.
(A) Anti-tetanus, (C) anti-KLH antibody titer fold increase as measured by ELISA on Day 15 and 43 (15 days after vaccination). Fold-increase in antibody titers were calculated by dividing post-anti-OX40 titers by pre-anti-OX40 titers. (B) Tetanus-specific T cell proliferation was measured on Day 43 for Arm A and Day 15 for Arm B, respectively 15 days after vaccination. Data are presented as fold changes compared to the proliferation prior to OX40 administration. * p< 0.05, ** p< 0.001.
