FIGURE 3.
Proliferation, IFN-γ production, and cytotoxic activity of γδ T cells in patients treated with zoledronate + IL-2. PBMC were obtained from seven patients treated with zoledronate + IL-2, before starting treatment (month 0), and 3, 9, and 12 mo after treatment. Cells were cultured in vitro with IPP and IL-2, as described in Materials and Methods. Proliferation was evaluated 7 d later, whereas IFN-γ production and BLT-esterase activities were assessed in the 48 and 24 h supernatants, respectively. O.D., absorbance. Points, mean; bars, SD.