Figure 3.
N-acetylcysteine (NAC) blocks PCP-evoked t-maze deficits. (a) Mean (± SEM) accuracy in a discrete-trial T-maze task following an injection of PCP (0–3 mg/kg, SC; n = 4–13/group as indicated in the bars of the graph). Pretreatment (60 min) with PCP (1–3 mg/kg, SC) dose-dependently produced working memory deficits evident as a decrease in the percent of correct choices during ten daily trials; ANOVA yielded a main effect of treatment (F3,33 = 41.99, P < 0.001). * indicates a difference from controls, Tukey HSD, p<.05. (b) Mean (± SEM) accuracy in a discrete-trial T-maze task in rats pretreated (90 min) with NAC (90 mg/kg, IP; n = 7–29/group) prior to PCP (0–3 mg/kg, SC). NAC administration reverses PCP-induced working memory deficits; ANOVA yielded a main effect of treatment (F5,92 = 25.5, P < 0.001). * indicates a difference relative to rats receiving saline alone (sal + 0 PCP), Tukey HSD, p<.05. # indicates a difference relative to rats receiving saline and respective dose of PCP, Tukey HSD, p<.05.