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Number of Participants with Drug-Related Grade 3 and 4 Toxicities by Cohort
| Cohort 1 (n=3) | Cohort 2 (n=3) | Cohort 3 (n=6) | Cohort 4 (n=6) | |||||
|---|---|---|---|---|---|---|---|---|
| Grade 3 | Grade 4 | Grade 3 | Grade 4 | Grade 3 | Grade 4 | Grade 3 | Grade 4 | |
| Elevated transaminases | 2 | 1* | ||||||
| Leukopenia | 1 | 2 | ||||||
| Hyperglycemia | 2 | 1 | ||||||
| Nausea | 2 | 2 | ||||||
| Vomiting | 1 | 1 | ||||||
| Hyponatremia | 2 | |||||||
| Fatigue | 2 | |||||||
| Dehydration | 1 | 1 | ||||||
Dose-limiting toxicity
