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. Author manuscript; available in PMC: 2014 Jan 20.

Published in final edited form as: ACS Nano. 2011 Mar 2;5(4):2756–2769. doi: 10.1021/nn200328m

(A) FITC-labeled, PEI-coated MSNPs (25 μg/mL) were used to determine cellular association at 3 h by flow cytometry and confocal microscopy. The flow measurement used mean fluorescence intensity (MFI) units to study the cellular association of the particles. The MFIs of the particles coated with the 10 and 25 kD polymers is significantly higher in differentiated cells compared to undifferentiated cells; (B) Confocal microscopy images showing the cellular localization of FITC-MSNP-PEI 10 kD in undifferentiated and differentiated cells. A significant fraction of the labeled particles are attached to the surface membrane of differentiated cells. *p < 0.05 compared with control.

(A) FITC-labeled, PEI-coated MSNPs (25 μg/mL) were used to determine cellular association at 3 h by flow cytometry and confocal microscopy. The flow measurement used mean fluorescence intensity (MFI) units to study the cellular association of the particles. The MFIs of the particles coated with the 10 and 25 kD polymers is significantly higher in differentiated cells compared to undifferentiated cells; (B) Confocal microscopy images showing the cellular localization of FITC-MSNP-PEI 10 kD in undifferentiated and differentiated cells. A significant fraction of the labeled particles are attached to the surface membrane of differentiated cells. *p < 0.05 compared with control.