Figure 2.
Extracellular glutamate concentrations in dialysate samples from NAc of ethanol dependent (EtOH) and nondependent (CTL) mice collected at baseline and after administration of 1 or 2 g/kg ethanol gavage. (a) Extracellular glutamate (GLUEX; μM) levels were approximately twofold higher in EtOH (n=19) compared with CTL (n=16) mice. Analysis indicated that EtOH mice displayed significantly higher baseline of GLUEX levels than CTL mice, but there was no effect of ethanol gavage in either group or either dose. *P<0.05 significantly differs from CTL values. (b) Significantly higher baseline GLUEX levels in EtOH mice compared with CTL mice was confirmed by expressing data collapsed across Dose and Time factors. *P<0.05 significantly differs from CTL group. (c) Administering 1 g/kg ethanol by gavage did not alter GLUEX levels in either EtOH or CTL groups of mice; data are expressed as percent of average baseline values for EtOH and CTL groups. (d) Administration of 2 g/kg ethanol by gavage did not significantly alter GLUEX levels in either EtOH or CTL groups; data are expressed as percent of average baseline values for EtOH and CTL groups.