Table - PMC

. 2013 Dec 17;170(8):1459–1581. doi: 10.1111/bph.12445

Nomenclature	5-HT4 receptor	5-ht5a receptor	5-ht5b receptor	5-HT6 receptor	5-HT7 receptor
HGNC, UniProt	HTR4, Q13639	HTR5A, P47898	HTR5BP, P31387	HTR6, P50406	HTR7, P34969
Principal transduction	G_s	G_i/G_o	None identified	G_s	G_s
Selective agonists (pK_i)	ML 10302 (Partial agonist) (7.9 – 9.0) 121,123,179–181, BIMU 8 (7.3) 138, RS67506 (pEC₅₀ 8.8 - Rat) 154	–	–	E-6801 (Partial agonist) (8.7) 157, WAY-181187 (8.7) 202	E55888 (8.6) 132
Selective antagonists (pK_i)	RS 100235 (8.7 – 12.2) 138,200, SB 204070 (9.8 – 10.4) 120,179,180,210, GR 113808 (9.3 – 10.3) 117,120,123,138,180,200,210	SB 699551 (8.2) 139	–	SB399885 (9.0) 156, SB 271046 (8.9) 133, SB357134 (8.5) 134, Ro 63-0563 (7.9 – 8.4) 126,204	SB269970 (8.6 – 8.9) 207, SB656104 (8.7) 145, SB 258719 (Inverse agonist) (7.5) 208
Radioligands (K_d)	[123I]SB 207710 (8.6x10^-11 M - Pig) 135, [3H]GR 113808 (Antagonist) (5x10^-11 – 2x10^-10 M) 117,120,181,210, [3H]RS 57639 (Agonist) (2x10^-10 M - Guinea pig) 127, [11C]SB207145 (Antagonist) (2.8x10^-9 M) 174	[125I]LSD (Agonist, Full agonist) (2x10^-10 M) 148, [3H]5-CT (Agonist, Full agonist) (2.5x10^-9 M) 148	[125I]LSD, [3H]5-CT	[3H]5-CT (Agonist), [125I]SB258585 (Antagonist) (1x10^-9 M) 156, [3H]LSD (Agonist, Full agonist) (2x10^-9 M) 125, [3H]Ro 63-0563 (Antagonist) (5x10^-9 M) 126	[3H]5-CT (Agonist) (4x10^-10 M) 207, [3H]SB269970 (Antagonist) (1.2x10^-9 M) 207, [3H]5-HT (Agonist, Full agonist) (1x10^-9 – 7.94x10^-9 M) 118,206, [3H]LSD (Agonist, Full agonist) (2.51x10^-9 – 3.16x10^-9 M) 206