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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Cancer Immunol Res. 2013 Jul;1:10.1158/2326-6066.CIR-13-0034. doi: 10.1158/2326-6066.CIR-13-0034

Table 3.

Relationship of TIL subsets to tumor and TIL PD-L1 expression

Tumor
 TILs
All Specimens n=39a PD-L1 (−) n=15 PD-L1 + n=24 p-valueb PD-L1 (−) n=11 PD-L1 + n=28 p-valueb
Intratumoral CD4:CD8, n (%)
    CD4 ≥ CD8 16 (41) 12 (80) 4 (17) < 0.001 9 (82) 7 (25) 0.003
    CD8 > CD4 23 (59) 3 (20) 20 (83) 2 (18) 21 (75)
Peritumoral CD4:CD8, n (%)
    CD4 ≥ CD8 35 (90) 15 (100) 20 (83) 0.146 11 (100) 24 (86) 0.309
    CD8 > CD4 4 (10) 0 (0) 4 (17) 0 (0) 4 (14)
All Specimens n=40a PD-L1 (−) n=15 PD-L1 + n=25 p-valueb PD-L1 (−) n=11 PD-L1 + n=29 p-valueb
CD8 Intratumoral, n (%)
    ≤ 60/HPF 31 (78) 15 (100) 16 (64) 0.015 11 (100) 20 (69) 0.043
    > 60/HPF 9 (22) 0 (0) 9 (36) 0 (0) 9 (31)
CD8 Peritumoral, n (%)
    ≤ 60/HPF 14 (35) 12 (80) 2 (8) <0.001 10 (91) 4 (14) < 0.001
    > 60/HPF 26 (65) 3 (20) 23 (92) 1 (9) 25 (86)
a

39 specimens had TILs present and tissue available for CD4 staining. 40 specimens had TILs present and material for CD8 staining.

b

Fisher's exact test