Figure 3. Resident memory T cells within the brain can provide protection against local infection.
Mice were seeded with OT-I.CD45.1 T cells before intranasal (i.n.) or intraperitoneal (i.p) infection with VSV-OVA. On day 20 p.i. mice were challenged intracranially with LM-OVA. The proportion of OT-I T cells of the total CD8+ T cell population in the (A) spleen and (B) lymph node and (C) the number of OT-I CD8 T cells in the brain on day 20 p.i. Bars represent the mean + SEM (n = 6) data is representative of 2 independent experiments. (D) Survival (measured as a loss of > 20% of starting weight) of animals primed either i.p or i.n. with VSV-OVA and challenged i.c. with LM-OVA. Shown is the mean + SEM (n = 15). Data is pooled from 3 independent experiments.