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. Author manuscript; available in PMC: 2014 Jan 6.
Published in final edited form as: Sci Transl Med. 2012 May 2;4(132):10.1126/scitranslmed.3003787. doi: 10.1126/scitranslmed.3003787

Fig. 3.

Fig. 3

Vascular COX-2 restrains thrombogenesis. Shown is thrombogenesis in the cremaster arterioles after laser-induced injury in COX-2 mutant mice, PGI2 receptor (IP) knockout mice, and thromboxane receptor (TP) knockout mice. Thrombus formation was visualized in real time with fluorescently labeled platelets. (A to C) Median integrated fluorescence intensity of platelets representing thrombus formation after laser injury for (A) COX-1 knockdown and COX-2 knockdown mice, (B) thromboxane receptor (TP) knockout mice and PGI2 receptor (IP) knockout mice, and (C) vascular COX-2 knockout mice (20 to 36 thrombi from two to four mice).