TABLE 2.
Chemokine receptor nomenclature and key immunoregulatory functions
| Name | CD# | Common Aliases | Accession Number |
Key Immunoregulatory Functions | |
|---|---|---|---|---|---|
| Human | Mouse | ||||
| G Protein-Coupled Chemokine Receptors | |||||
| CXCR1 | CD181 | IL8RA | P25024 | Q810W6 | Neutrophil trafficking |
| CXCR2 | CD182 | IL8RB | P25025 | P35343 | B-cell lymphopoiesis |
| Neutrophil egress from bone marrow | |||||
| Neutrophil trafficking in innate immunity | |||||
| CXCR3 | CD183 | IP10/Mig R | P49682 | O88410 | Type 1 adaptive immunity |
| CXCR4 | CD184 | fusin | P61073 | P70658 | Hematopoiesis |
| Organopoiesis | |||||
| Adaptive Immunity | |||||
| CXCR5 | CD185 | BLR-1 | P32302 | Q04683 | B and T-cell trafficking in lymphoid tissue to B-cell zone/follicles |
| CXCR6 | CD186 | BONZO, STRL33 | O00574 | Q9EQ16 | Innate lymphoid cell function |
| Adaptive immunity | |||||
| CCR1 | CD191 | CC CKR1, MIP-1α/RANTES R | P32246 | P51675 | Innate Immunity |
| Adaptive Immunity | |||||
| CCR2 | CD192 | CC CKR2, MCP-1-R | P41597 | P51683 | Monocyte trafficking |
| Type 1 adaptive immunity | |||||
| CCR3 | CD193 | CC CKR3, Eotaxin receptor | P51677 | P51678 | Type 2 adaptive immunity |
| Eosinophil distribution and trafficking | |||||
| CCR4 | CD194 | CC CKR4 | P51679 | P51680 | Homing of resident memory T cells to skin |
| Thymopoiesis; Th2 immune response | |||||
| CCR5 | CD195 | CC CKR5 | P51681 | P51682 | Type 1 adaptive immunity |
| CCR6 | CD196 | P51684 | O54689 | iDC trafficking; GALT development | |
| Th17 adaptive immune responses | |||||
| CCR7 | CD197 | EBI-1, BLR-2 | P32248 | P47774 | mDC, and B and T-cell trafficking in lymphoid tissue to T-cell zone |
| Egress of T cells from tissue | |||||
| CCR8 | CDw198 | P51685 | P56484 | Thymopoiesis | |
| Immune surveillance in skin | |||||
| Type 2 adaptive immunity | |||||
| CCR9 | CDw199 | P51686 | Q9WUT7 | Thymopoiesis; Homing of T cells to gut. | |
| GALT development and function | |||||
| CCR10 | P46092 | Q9JL21 | Humoral immunity at mucosal sites | ||
| Immune surveillance in skin | |||||
| XCR1 | P46094 | Q9R0M1 | Ag cross-presentation by CD8+ DCs | ||
| CX3CR1 | Fractalkine receptor | P49238 | Q9Z0D9 | Patrolling monocytes in innate immunity | |
| Microglial cell and NK cell migration | |||||
| Type 1 adaptive immunity | |||||
| Atypical Chemokine Receptors (New Nomenclature) | |||||
| ACKR1 | CD234 | DARC; Duffy | Q16570 | Q9QUI6 | Chemokine transcytosis |
| Chemokine scavenging | |||||
| ACKR2 | D6, CCR9 (unofficial), CCR10 (unofficial) | O00590 | Y12879 | Chemokine scavenging | |
| ACKR3 | CXCR7; RDC1 | P25106 | P56485 | Heart valve development | |
| Shaping chemokine gradients for CXCR4 | |||||
| ACKR4 | CCRL1; CCX-CKR, CCBP2, CCR11 | Q9NPB9 | Q924I3 | Chemokine scavenging | |
| CCRL2 (ACKR5) | CKRX, CRAM-A, | O00421 | O35457 | Not defined | |
| L-CCR, CRAM-B, HCR, CCR11 | |||||
| PITPNM3 (ACKR6) | Nir1 | AAI28584.1 | Breast cancer metastasis | ||
iDC, immature dendritic cell; mDC, mature dendritic cell.