Table 1.
Top associations in the HLA region
| SNP | Alleles |
MAFb |
Observed or Imputed in Dataset 1 / 2 |
Dataset 1 |
Dataset 2 |
Meta analysis |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| maj/mina | Case | Control | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
| HLA-DRA | ||||||||||
| rs112357081 | TCTAA/T | 0.59 | 0.33 | I / - | 2.89 (2.43-3.44) | 1.01×10−32 | - | - | - | - |
| rs3135394 | A/G | 0.27 | 0.11 | I / O | 3.52 (2.83-4.38) | 2.47 ×10−29 | 3.52 (3.10-3.99) | 1.14×10−85 | 3.52 (3.02-4.10) | 5.22×10−113 |
| HLA-DQB1 | ||||||||||
| rs115575857 | A/G | 0.29 | 0.12 | I / I | 3.25 (2.61-4.05) | 4.10 ×10−26 | 3.65 (3.22-4.14) | 3.70×10−90 | 3.53 (3.03-4.11) | 7.65×10−114 |
| rs3129716 | T/C | 0.29 | 0.12 | I / O | 3.29 (2.66-4.09) | 2.11 ×10−27 | 3.51 (3.10-3.97) | 7.74×10−87 | 3.45 (2.97-4.00) | 4.59×10−112 |
| HLA-DQA1 | ||||||||||
| rs116232857 | A/G | 0.64 | 0.42 | I / I | 2.83 (2.37-3.38) | 9.05 ×10−31 | 2.42 (2.19-2.67) | 1.14×10−67 | 2.53 (2.24-2.86) | 1.33×10−96 |
| rs9271588 | T/C | 0.27 | 0.48 | I / O | 0.35 (0.29-0.42) | 1.93 ×10−28 | 0.43 (0.39-0.48) | 4.62×10−59 | 0.41 (0.36-0.46) | 1.37×10−85 |
a
Major allele / minor allele. Odds ratio for each variant indicates disease risk conferred by the minor allele.
b
The minor allele frequency (MAF) was calculated using the combined Datasets 1 and 2, except for rs112357081, for which the MAF is derived from Dataset 1 only.