Table 3.
Cross-neutralization of escape mutants by human monoclonal antibodies (reciprocal neutralization titers): Type 1 poliovirus
| Escape clone | A12 escape mutants | H2 escape mutants | 1o escape mutants | Sabin 1 | |||||
| Mutations | ES15-1/5 | ES15-1/6 | ES13-3 | ES13-5 | ES13-10 | EX4-1 | EX4-2 | EX4-5 | Control |
| V 1166 E | V 1166 E | K 1144 R | K 1144 E | V 1107 A | D 1298 N | D 1298 G | D 1298 G | ||
| I 1090 M | D 1288 N | D 1219 G | S 3058 C | D 3181 Y | L 1234 V | ||||
| Antibody | |||||||||
| A12 | <1 | <1 | 144 | >181 | 45 | 114 | 144 | 144 | 114 |
| F12 | <1 | <1 | >181 | >181 | >181 | >181 | >181 | >181 | >181 |
| H2 | >181 | >181 | <1 | <1 | <1 | 18 | <1 | <1 | 144 |
| 1o | 36 | 11 | 18 | 23 | 3 | <1 | <1 | <1 | 45 |