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Functional assays of TICAM-1 and TICAM-2 mutants in mammalian cells. (A) TICAM-2–dependent IFN-β promoter activation. IFN-β promoter activity was reduced by the E87A/D88A/D89A mutation in TICAM-2. (B) TICAM-2-TICAM-1–dependent IFN-β promoter activation. IFN-β promoter activity was reduced by the E87A/D88A/D89A mutation in TICAM-2. (C) TICAM-2-TICAM-1–dependent IFN-β promoter activation. The mutation of R522/K523 in TICAM-1 reduced IFN-β promoter activation.
