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. Author manuscript; available in PMC: 2013 Dec 7.
Published in final edited form as: Nat Cell Biol. 2010 Apr 11;12(5):10.1038/ncb2047. doi: 10.1038/ncb2047

Figure 8. The Myc/Skp2/Miz1 complex is overexpressed and correlated with RhoA expression in metastatic prostate cancer samples.

Figure 8

(a) The expression of RhoA, Myc, Skp2, and Miz1 in representative cases of primary prostate adenocarcinomas that remained localized (L) or developed metastasis (M). The labeling indices of RhoA, Myc, Skp2, and Miz1 were appeared lower in the localized tumour but indicated significant overexpression in the case with metastasis. Original magnification, × 400; Scale bar = 100 μm. (b) The expression of RhoA, Myc, Skp2, and Miz1 in primary prostate cancer versus metastatic prostate cancer. (c) The working model for SCF-Skp2 E3 ligase-dependent and -independent functions.