Figure 2.
Performance of Fmr1 KO mice and wildtype littermates on the acquisition and four serial reversals of a pairwise visual discrimination. For stimulus group 1 (wildtype n = 11, Fmr1 KO n = 10), the correct stimulus was salient on reversals 1 and 3 (an easy reversal) and non-salient on reversals 2 and 4 (a difficult reversal). For stimulus group 2 (wildtype n = 9, Fmr1 KO n = 9), this pattern was reversed. (A and B) Fmr1 KO mice committed significantly more errors than wildtype littermates (* = p < .05) during the second reversal stage, but only when the correct stimulus was non-salient. (C) An analysis of the type of errors committed on reversal 2 by stimulus group 1 revealed that Fmr1 KO mice in stimulus group 1 did not commit significantly more perseverative errors (session performance ≤ 40% correct) than wildtype littermates, but did commit significantly more (* = p < .01) learning errors (session performance 41% – 80% correct).