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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: Cancer Res. 2013 Oct 1;73(22):10.1158/0008-5472.CAN-13-0987. doi: 10.1158/0008-5472.CAN-13-0987

Figure 1. Recruitment of MDSC were increased while the infiltration of CD8+ and CD4+ T cells were decreased with tumor progression.

Figure 1

(a) Tumor weights from mice on days 5, 10, 15, and 19 after i.v. challenge with 106 LLC tumor cells. ***p<0.001 in comparisons to day 5, day 10 compared to day 5, day 15 compared to day 10 and day 19 compared to day 15 (n=5 mice/time point, 3 replicate experiments). (b) H & E staining of lung tissue at indicated time points (c) FACS plots showing percentages of MDSC in tumor on days 10, 15 and 19 post-LLC injection, **p<0.01 day 19 vs day 15 and for day 10 vs day 15. (d) Characterization of MDSC subsets by flow cytometry using additional MDSC markers Ly-6C, Ly-6G and F4/80. (e) FACS plots showing CD8+ and CD4+ T cells in tumor at indicated times, left to right panels *p<0.05 for both CD4+ and CD8+ T cells, day 10 vs day15 vs day19 (n=5 mice/time point, 3 replicate experiments).