Figure 2.
(A) Concentration–time profiles of metformin in healthy volunteers after oral administration of 500 mg three times daily (filled circles) and during cotreatment with trimethoprim (open circles). (B) Volunteers wild-type (wt) for MATE1 and OCT2. (C) Volunteers with polymorphic (poly) MATE1 (rs2289669) and wild-type OCT2. (D) Volunteers with wild-type MATE1 and polymorphic OCT2 (rs316019). (E) Volunteers with polymorphic MATE1 and OCT2. Each point represents the mean ± SEM. *P < 0.05 and **P < 0.01 (comparison at the respective time point)