Fig. 3.
Identification of immune-responsive genes by using DNA microarrays. (A) The fold change in genes with significant change in expression levels when Mtb bacilli were grown in BALB/c (red) vs. SCID (blue) mice at 7, 14, 21, and 28 days after infection (n = 122, 67 up- and 55 down-regulated in BALB/c relative to 7H9 samples). (B) The dendogram tree of hierarchical clustering analysis of genes expressed in BALB/c or SCID mice and broth over the first 28 days after infection. List of genes is provided in the supporting information.