Fig. 3.
Results for (A) fraction of perfused vessels and (B) effective vascular density as a function of vessel diameter and vessel wall pore size. The dashed line depicts the region within which vascular normalization is beneficial (referred to as optimal perfusion region), the circle shows the initial values, and the solid lines show potential paths of the treatment. The fraction of the well-perfused vessels and the effective vascular density become optimal for uncompressed (larger diameter) and low-permeable (smaller vessel wall pore size) vessels. The fraction of perfused vessels decreases if the tumor vessels are compressed or hyperpermeable. Vascular normalization is beneficial for compressed and hyperpermeable vessels.