Table 1. Human High-Grade Brainstem Gliomas overexpress PDGFRα.
| Brainstem Glioma Grade | PDGFR IHC | Biopsy or Autopsy | Age of Patient |
|---|---|---|---|
| Pontine Grade IV | 1+ | Autopsy | 15 year-old |
| Pontine Grade IV | Negative | Autopsy | 4 year-old |
| Pontine Grade IV | 1+ | Autopsy | 7 year-old |
| Pontine Grade III | Negative | Autopsy | 9 year-old |
| Pontine Grade IV | Negative | Autopsy | 7 year-old |
| Pontine Grade II | Negative | Autopsy | 8 months |
| Pontine Grade IV | 1+ focal | Autopsy | 7 year-old |
| Pontine Grade IV | Negative | Autopsy | 10 year-old |
| Pontine Grade IV | 1+ focal | Autopsy | 5 year-old |
| Pontine grade IV | 2+ | Autopsy | 6 year-old |
| Pontine grade IV | 1+ | Biopsy | 10 year-old |
| Pontine grade IV | 2+ | Biopsy | 4 year-old |
| Pontine Grade II | 1+ | Biopsy | 4 year-old |
| Pontine Grade III | 1+ | Biopsy | 4 year-old |
| Pontine Grade IV | Negative | Biopsy | 8 year-old |
| Pontine grade IV | 2+ | Biopsy | 4 year-old |
| Pontine grade IV | 2+ | Biopsy | 10 year-old |
| Midbrain Grade III | 2+ | Biopsy | 2 year-old |
PDGFR IHC (negative = no staining, 1+ = weak staining of tumor cells, and 2+ = strong immunostaining of tumor cells)