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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Nat Struct Mol Biol. 2013 Sep 29;20(11):1250–1257. doi: 10.1038/nsmb.2679

Figure 2.

Figure 2

Promiscuous binding of RNA by PRC2 in vitro. (a) Representative EMSAs and the corresponding binding curves show binding of PRC2 to HOTAIR 1–300, HOTAIR 400, antisense (as) HOTAIR 1–300 and E. coli MBP 1–300. Kd and Hill coefficients represented with data-range from two independent experiments performed on different days. (b) Binding competition experiment with unlabeled competitors MBP 1–300 and HOTAIR 400, radiolabeled HOTAIR 400 and PRC2 4m.