Table 1.
Genes with significantly altered expression 2 h after TcdA and TcdB injection
| Gene | Fold changea in expression after challenge by time point and toxin |
|||||||
|---|---|---|---|---|---|---|---|---|
| 2 h |
6 h |
16 h |
||||||
| TcdA | TcdB | TcdA+B | TcdA | TcdB | TcdA+B | TcdA | TcdB | |
| Dusp1 | 4.8 | 1.3 | 4.4 | 6.4 | −1.0 | 10.1 | 1.9 | 1.1 |
| Rhob | 4.2 | 1.2 | 3.8 | 4.0 | 1.5 | 4.8 | 2.1 | 1.3 |
| Atf3 | 4.0 | 1.4 | 3.5 | 2.7 | −1.2 | 4.0 | 1.2 | −2.0 |
| Sprr1a | 3.4 | 1.5 | 3.7 | 4.9 | −1.1 | 8.8 | −1.6 | −1.4 |
| C3 | 2.8 | 1.6 | 1.2 | 2.2 | 1.6 | 3.2 | 5.7 | 1.9 |
| Areg | 2.6 | −1.1 | 2.5 | 12.8 | 2.4 | 15.5 | 14.9 | 5.1 |
| Cxcl10 | 2.6 | 2.0 | 6.8 | 11.3 | 1.3 | 13.3 | 4.7 | 2.2 |
| Insig1 | 2.5 | 1.5 | 1.8 | −1.9 | −1.1 | −1.4 | −2.3 | −1.5 |
| Errfi1 | 2.5 | 1.1 | 2.2 | 3.4 | −1.0 | 5.5 | −1.2 | −1.4 |
| Egr1 | 2.3 | −1.1 | 1.5 | 2.5 | 1.9 | 5.0 | 3.7 | 1.4 |
| Zfp36 | 2.2 | 1.1 | 2.0 | 2.9 | 1.8 | 3.4 | 2.2 | 1.2 |
| Hmgcs1 | 1.8 | 1.2 | 1.6 | −1.2 | 1.0 | −1.1 | 2.4 | 1.5 |
| Jun | 1.8 | 1.3 | 1.6 | 1.4 | 1.2 | 1.6 | −1.9 | −1.1 |
| Gm11545 | 1.6 | 1.1 | 1.7 | 7.3 | 1.9 | 8.2 | 5.6 | 3.8 |
| 1700006J14Rik | −1.8 | −1.3 | −1.2 | −1.3 | 1.4 | −1.1 | −1.6 | −1.1 |
| H3f3b | −2.0 | −1.5 | −1.3 | 1.1 | 2.0 | 1.4 | 1.8 | 1.4 |
| Lrrtm1 | −2.3 | −2.0 | −2.2 | −2.3 | −1.5 | −2.5 | −1.9 | −1.9 |
| Slc8a1 | −2.3 | −1.3 | −1.7 | −3.4 | 1.4 | −2.7 | −2.9 | 1.0 |
| Cxcl1 | 4.4 | 2.2 | 6.5 | 9.7 | 1.1 | 8.1 | 3.3 | 1.6 |
| Mtch2 | −1.5 | −2.0 | −1.7 | −1.1 | 2.0 | −1.6 | −1.5 | −1.2 |
| Slc20a1 | −1.9 | −2.1 | −2.5 | −2.5 | 1.7 | −2.7 | −4.4 | −1.5 |
a
Average fold changes relative to sham challenge are shown (values of −1.1 and +1.1 imply a 10% decrease and increase, respectively, in gene expression). The cutoff for determining a differentially expressed gene is q < 0.01 (see Materials and Methods).