Table 3.
Daptomycin cure rate of VRE infections by daptomycin MICa
| Daptomycin MIC, μg/mlb | Cure, nc | Total, nd | Cure rate, % (95% CI)e | References |
|---|---|---|---|---|
| ≤1 | 6 | 7 | 85.7 (60.6–100) | 79, 225–227 |
| 2 | 12 | 19 | 63.2 (37.5–88.9) | 79, 225, 228–231 |
| 4 | 33 | 44 | 75.0 (52.3–97.7) | 79, 225, 230–233 |
| ≥8 | 0 | 5 | 0.0 | 75, 160, 183, 234, 235 |
a
VRE, vancomycin-resistant Enterococcus, including E. faecalis, E. faecium, E. raffinosus, and E. gallinarum.
b
MIC by broth microdilution, Etest, or automated method. The isolate with the highest MIC was included. Etest results were rounded up to nearest dilutional integer for comparison.
c
Microbiological or clinical cure. Where both were presented in a relevant study, the lower cure rate was chosen for a more conservative estimate.
d
Data pooled from multiple studies and case reports, with additional data clarification by study authors where possible. See Table S2 in the supplemental material for further details.
e
95% CI, 95% confidence interval.