Figure 2. Schematic depiction of the regulation, partners and selected functions of emerin at the nuclear envelope. Depiction of emerin and other LEM-domain proteins (Lem2, Man1 and Lap2β) at the inner membrane (IM) of the nuclear envelope. Double-headed arrows connect direct binding partners, including emerin (dark gray), SUN-domain proteins, BAF, HDAC3 and Man1. Direct binding to lamins is not indicated. Emerin has roles in signaling, mechano-transduction, nuclear architecture, chromatin tethering and gene regulation. Also depicted are enzymes and pathways that directly target or regulate emerin. “L” indicates the LEM-domain. “L-prime” [L’] in Lap2β indicates the DNA-binding “LEM-like” domain. OGT, O-GlcNAc transferase. OM, outer membrane.