. 2013 Nov;87(22):12489–12495. doi: 10.1128/JVI.01845-13

Table 1.

Features of MERS-CoV accessory proteins

Viral gene/protein	Genome positions (bp)	No. of amino acids	Predicted molecular mass (kDa)	Putative functional domain(s)^a	Prediction of cellular localization/our observation^b
ORF 3/p3	25,531–25,842	103	11	1 TMD, N-glycosylation site	Secretory pathway^c/ERGIC and TGN
ORF 4a/p4a	25,851–26,180	109	12	dsRNA-binding domain	Signal peptide not found/cytoplasm and nucleus
ORF 4b/p4b	26,092–26,832	246	29	1 TMD	Nuclear localization signal^d/cytoplasm and nucleus
ORF 5/p5	26,839–27,513	224	25	3 TMDs	Secretory pathway^c/ERGIC

Putative functional domain(s) were predicted by TMpred (40) and DELTA-BLAST (domain enhanced lookup time accelerated BLAST). TMD, transmembrane domain.

ERGIC, endoplasmic reticulum-Golgi intermediate compartment; TGN, trans-Golgi network.

Predicted by TargetP (41).

Predicted by WoLF PSORT (42).