Figure 2. Plasma levels of markers of leukocyte, platelet, endothelial and coagulation activation according to the presence and severity of coronary artery disease.
Patients were divided into categories based on the severity of CAD as assessed with CCTA. Patients who did not undergo CCTA because of a high calcium score were considered as a separate category (“Extremely Calcified”). A total of five markers were measured in all patients (panel A-E). Shaded area demonstrates the range of the measured markers in plasma from healthy controls (n=10). NPP (from n=85 healthy volunteers) is indicated by a horizontal dotted line.
CAD = Coronary Artery Disease; CCTA = Coronary Computed Tomographic Angiography; dsDNA = Double Stranded DNA; NPP = Normal Pooled Plasma; MPO = myeloperoxidase; VWF = Von Willebrand Factor; TAT = Thrombin-Antithrombin; PMN = Polymorphonuclear; α1-PI = alpha 1-proteinase inhibitor; PF4 = Platelet Factor 4
* = p<0.05; ** = p<0.01; *** = p<0.001.