Table 2.
ROI-based measurements in gray matter structures of the in vivo and ex vivo mouse brain DTI datasets. The volume (mm3), ADC (mm2/s) and FA in several major gray matter structures are presented as mean ± standard deviation from in vivo (n=8) and ex vivo (n=10) DTI data. Gray matter segmentations defined in the in vivo atlas were transformed to individual mouse brain data and used as ROIs.* p < 0.01, ** p < 0.005. The ADC and FA values of the ventricles are not shown because the low signal-to-ratio of diffusion-weighted signals in the ventricles resulted in unreliable estimates of diffusion parameters in this region.
| Structures | Volume (mm3) | ADC (×10−3 mm2/s) | FA | |||
|---|---|---|---|---|---|---|
|
| ||||||
| In vivo | Ex vivo | In vivo | Ex vivo | In vivo | Ex vivo | |
|
| ||||||
| Neocortex | 100.4±5.1 | 99.5±4.9 | 0.55±0.02 | 0.45±0.10 | 0.21±0.01** | 0.19±0.01 |
| Hippocampus | 25.0±1.4 | 26.5±2.4 | 0.56±0.03** | 0.45±0.10 | 0.25±0.02 | 0.25±0.02 |
| Striatum | 21.0±0.9* | 23.0±1.8 | 0.52±0.03* | 0.41±0.10 | 0.27±0.02** | 0.18±0.01 |
| Thalamus | 20.6±0.9 | 20.7±1.4 | 0.53±0.03** | 0.39±0.07 | 0.37±0.03** | 0.27±0.01 |
| Septum | 1.6±0.1 | 1.8±0.2 | 0.63±0.05** | 0.41±0.10 | 0.35±0.03** | 0.25±0.01 |
| Cerebellum | 54.9±3.0 | 55.0±1.6 | 0.50±0.03** | 0.37±0.09 | 0.35±0.02** | 0.29±0.02 |
| Ventricles | 8.42±0.71** | 3.36±0.47 | --- | --- | --- | --- |