Table 1.
Genetic identity among treponemal strains compared to the Nichols strain based on whole genome sequencing (WGS) or whole genome fingerprinting (WGF).
| Strain | Place and year of isolation [reference] | Genome size as revealed by WGS (nt) | Estimated genome size by WGF (kb) | Reference (GenBank acc. no.) | Estimated genome sequence identity with Nichols (%)* |
|---|---|---|---|---|---|
| TPA Nichols | Washington, DC; 1912 Nichols and Hough, 1913 | 1,138,011 1,139,631** | Fraser et al., 1998 (AE000520.1) | 100 | |
| TPA Chicago | Chicago?; 1951 Turner and Hollander, 1957 | 1,139,281 | Giacani et al., 2010 (CP001752.1) | 99.95 | |
| TPA DAL-1 | Dallas; 1991 Wendel et al., 1991 | 1139.9 | Mikalová et al., 2010 | 99.97 | |
| TPA SS14 | Atlanta; 1977 Stamm et al., 1983 | 1,139,457 | Matějková et al., 2008 (CP000805.1) | 99.89 | |
| TPA Mexico A | Mexico; 1953 Turner and Hollander, 1957 | 1140.0 | Mikalová et al., 2010 | 99.88 | |
| TPE Samoa D | Western Samoa; 1953 Turner and Hollander, 1957 | 1,139,330 | D. Čejková et al., 2011 (CP002374) | 99.65 | |
| TPE CDC-2 | Akorabo, Ghana; 1980 Liska et al., 1982 | 1,139,744 | D. Čejková et al., 2011 (CP002375) | 99.64 | |
| TPE Gauthier | Congo; 1960 Gastinel et al., 1963 | 1,139,441 | D. Čejková et al., 2011 (CP002376) | 99.67 | |
| Fribourg-Blanc | Guinea; 1966 Fribourg-Blanc and Mollaret, 1969 | 1140.4 | Mikalová et al., 2010 | 99.57*** | |
| T. paraluiscuniculi Cuniculi A | Baltimore; ? Jacobsthal, 1920 | 1,133,390 | Šmajs et al., 2011 (CP002103) | 98.10 |
*
Genome sequence identity was calculated from whole genome sequence alignments including gaps in alignments.
**
The published genome sequence (Fraser et al., 1998) was modified by addition of insertion of a tprK-like sequence (1.3 kb) in the intergenic region between TP0126 and TP0127 (Šmajs et al., 2002) and addition 7 repetitive sequence (60 bp) in the arp gene (TP0433-TP0434).
***
identity based on whole genome fingerprinting (Mikalová et al., 2010)