Figure 3.
Immediate effects of a single injection of ketamine (20 mg/kg) on distance traveled in adolescent and adult rats. (A) Adolescent rats treated with ketamine (n=19) had significantly increased locomotor activity during the first 15 minutes immediately after a single ketamine exposure when compared to saline-treated adolescent controls (n=20; p<0.05). Their total distance traveled was also significantly higher than controls (p<0.05). (B) Ketamine treated adults (n=19) exhibit no differences in distance traveled across time or total distance traveled compared to their respective saline-treated controls (n=20). Data are represented as mean distance traveled (mean ± SEM, in cm). *Significantly different from saline-treated controls (p<0.05).