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. 2013 Sep 9;123(10):4410–4422. doi: 10.1172/JCI69369

Figure 4. sMICB impairs NK cell peripheral homeostasis and facilitates lung metastasis in experimental TRAMP-C2 lung metastatic model.

Figure 4

(A) Experiment design. (B) Representative images of H&E staining (left panel) and quantification of lung deposits of micrometastasis (arrowhead on micrograph, right arrowhead). (C) Representative dot plots (left panel) of flow cytometry analyses and pooled statistical data (right panel) demonstrating NK1.1 frequency in bone marrow, LNs, and spleens. *P < 0.05 in comparison with anti-sMICB treatment group and all animals injected with TRAMP-C2 cells. (D) Representative flow cytometry analyses and quantification of splenic BrdU+ NK cell accumulation over 5 days. Data are representative of 5 animals per subgroup and 3 independent experiments.