. 2013 Apr 1;2:469–476. doi: 10.1016/j.nicl.2013.03.013

Table 2.

VBM results.

Comparison	Brain region	Milliliters	X	Y	Z	P-value (corrected)
HC > ADS	Medial frontal gyrus	28.9	0	24	46	< 0.001
	Right inferior temporal gyrus	14.6	62	− 26	− 26	< 0.001
	Superior frontal gyrus	7.7	− 22	6	52	< 0.001
	Cingulate gyrus	6.1	14	− 8	44	< 0.001
	Frontal pole	5.0	42	52	16	< 0.001
	Inferior frontal gyrus	4.0	− 52	10	24	< 0.001
	Left hippocampus	3.4	− 12	− 44	10	< 0.001
	Angular gyrus	3.2	− 48	− 54	34	< 0.001
	Frontal pole	2.7	− 28	48	14	< 0.001
	Lingual gyrus	2.4	14	− 42	− 10	< 0.001
	Postcentral gyrus	1.8	− 56	− 16	36	< 0.001
	Precuneus	1.7	18	− 68	30	< 0.005
	Inferior frontal gyrus	1.4	54	12	22	< 0.005
	Right thalamus	.77	8	− 12	− 2	< 0.01
	Right amygdala	.70	16	− 14	− 12	< 0.01
HC > ‘Pure’	Precuneus cortex	9.12	18	− 56	14	< 0.001
	Right Inferior temporal gyrus	8.392	62	− 26	− 24	< 0.001
	Superior frontal gyrus	6.384	18	40	44	< 0.001
	Right thalamus	5.152	20	− 26	4	< 0.001
	Precentral gyrus	4.632	24	− 6	60	< 0.001
	Angular gyrus	4.496	− 50	56	38	< 0.001
	Middle frontal gyrus	4.168	− 28	− 2	48	< 0.001
	Inferior frontal gyrus	2.6	− 52	10	24	< 0.001
	Frontal pole	2.512	− 24	50	10	< 0.001
	Lateral occipital cortex	2.376	42	− 60	32	< 0.001
	Superior parietal lobule	1.704	− 16	− 56	58	< 0.001
	Intracalcarine cortex	1.448	− 22	− 70	6	< 0.001
	Paracingulate gyrus	1.296	0	36	32	< 0.001
	Postcentral gyrus	1.224	26	− 32	50	< 0.001
	Left thalamus	1.224	− 8	− 16	− 2	< 0.001
	Cingulate gyrus	1.168	14	− 6	46	< 0.001
	Left putamen	1.12	− 26	− 14	− 6	< 0.005
	Right putamen	1	26	− 16	− 6	< 0.005
HC > Poly	Superior frontal gyrus — medial region	15.464	0	24	46	< 0.001
	Right inferior temporal gyrus	9.2	62	− 8	− 32	< 0.001
	Middle frontal gyrus	7.656	34	20	52	< 0.001
	Superior frontal gyrus	6.192	− 28	22	50	< 0.001
	Right temporal pole	2.808	38	10	− 36	< 0.001
	Cingulate gyrus	2.408	0	− 10	24	< 0.001
	Precentral gyrus	1.984	− 44	4	24	< 0.001
Poly > ‘Pure’	Thalamus (bilateral)	1.976	6	− 16	16	< 0.001
	Parahippocampal gyrus	1.712	20	− 26	− 24	< 0.001
	Brain stem	1.04	− 10	− 26	− 16	< 0.005

All coordinates are presented in MNI space. Comparisons: Healthy controls vs. All Alcoholics (HC > ADS) — alcoholics less gray matter relative to controls. Total volume of significantly different cortex was 82.9 ml. Total volume of significantly different subcortex was 1.47 ml. Healthy controls vs. ‘Pure’ Alcoholics (HC > ‘Pure’) — areas in which alcoholics with only alcohol dependence display less gray matter relative to healthy controls. Total volume of significantly different cortex was 51.51 ml. Total volume of significantly different subcortex was 8.49 ml. Healthy controls vs. Polysubstance abusing alcoholics (HC > Poly) — areas in which alcoholics with polysubstance abuse or dependence display less gray matter relative to healthy controls. Total volume of significantly different cortex was 45.71 ml. Total volume of significantly different subcortex was 0 ml. Polysubstance abusing alcoholics vs. ‘Pure’ Alcoholics (Poly > ‘Pure’) — areas in which alcoholics with only alcohol dependence display less gray matter relative to alcoholics who are polysubstance abusers. The volume of significantly different tissue was 4.7 ml, the majority being subcortical.