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(A) Structural differences between nona- vs. decamer-specific TCR bound to Melan-A(ELA)/HLA− A∗0201. The green line identifies the hydrogen bond that is formed between CDR1α and Glu1 of the peptide. No favorable interactions were identified between M77-80 and the decamer variant of Melan-A. (B) In silico mutation results in NY-ESO-1 repertoire. The dramatic structural rearrangement of the mutated CDR3β confirms the importance of the central Gly.
