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. 2013 Jun 13;12(9):2568–2586. doi: 10.1074/mcp.M113.029561

Table I. Putative glycoproteins identified by mudPIT with links to pathogenesis.

Gene Acc. # Protein name Predicted MW (kDa) Function/sequence features Link to pathogenesis Subcellular localizationa Spect- counts Uni-pep Seq-cov%
HP0073 P14916 ureA 27.8 Urease alpha subunit Enables survival in acid Cytoplasm, surface 96 4 34.4
HP0072 P69996 ureB 61.6 Urease beta subunit Enables survival in acid Cytoplasm, surface 188 7 22.7
HP0527 NP_207323 cag7 230.1 cag pathogenicity island, type IV secretion Oncogene, gastric cancer Outer membrane 2 2 1.4
HP1563 P21762 tsaA 23.5 Alkyl hydroperoxide reductase Resists oxidative damage Cytoplasm 428 12 65.7
HP0325 O25092 flgH 27.8 Flagellar export Critical for motility Outer membrane 4 2 7.2
HP0010 P42383 groEL 61.5 Chaperone Gastric cancer-associated antigen, immunogen Cytoplasm, surface 576 18 37.3
HP0011 P0A0R3 groES 13.7 Chaperone Gastric cancer-associated antigen, immunogen Cytoplasm, surface 546 7 41.9
HP1161 O25776 fldA 18.5 Flavodoxin Critical metabolic gene Unknown 2 2 20.8
HP0653 P52093 pfr 20.3 Nonheme iron-containing ferritin Crucial for iron acquisition Cytoplasm 35 3 25.6
HP0389 AAD07454 sodB 25.9 Superoxide dismutase Resists oxidative damage Periplasm 10 4 28.9
HP0875 P77872 katA 61.5 Catalase Combats oxidative stress Periplasm, surface 91 6 18.0
HP0390 O25151 tagD 19.3 Adhesin thiol peroxidase Combats oxidative stress Periplasm 3 3 32.6
HP0243 P43313 napA 17.9 Neutrophil activation Immunomodulator, biofilm formation Cytoplasm, surface 9 3 25.5
HP0224 O25011 msrA 43.2 Methionine sulfoxide reductase Antioxidant, immunogen Cytoplasm 42 4 18.6
HP0317 AAD07380 babC 85.4 Outer membrane protein Adhesion, glycan binding Outer membrane 4 2 5.4
HP1243 AAD08288 babA 83.3 Outer membrane protein Adhesion, glycan binding Outer membrane 2 1 2.8
HP1177 AAD08221 hopQ 73.3 Outer membrane protein Present on disease-related strains Outer membrane 14 2 5.5
HP1205 P56003 tufB 45.9 Translation elongation factor Resistance to prolonged acid exposure Cytoplasm 10 4 17.1
HP1123 O25748 slyD 21.3 Peptidyl-prolyl cis-trans isomerase Important for urease assembly Cytoplasm 2 2 16.2
HP1195 P56002 fusA 80.9 Translation elongation factor Duodenal ulcer-related antigen Cytoplasm, surface 36 8 21.0
HP0027 P56063 icd 50.1 Isocitrate dehydrogenase Immunogen, induces humoral immune system Cytoplasm 21 4 15.6
HP0192 O06913 frdA 84.0 Fumarate reductase Immunogen, crucial for survival in gastric mucosa Inner membrane 28 5 13.2
HP0109 P55994 dnaK 70.6 Chaperone and heat shock protein 70 Stress induced surface adhesion, immunogen Cytoplasm, surface 6 3 8.7
HP0082 AAD07152 tlpC 79.1 Methyl-accepting chemotaxis transducer Assist colonization of the stomach Inner membrane 10 3 7.6
HP1019 AAD08063 htrA 50.6 Serine protease, chaperone Disrupts intracellular adhesion Periplasm, secreted 5 2 6.6
HP0099 AAD07167 tlpA 78.4 Methyl-accepting chemotaxis protein Chemotaxis receptor Outer membrane 3 1 3.2

a Subcellular localization was based on literature reports or predicted using PSORTb v.3.0.