Figure 2.
Response of immunohistochemical RCC xenografts to VDA-mTOR inhibition in vivo. A, photomicrographs of H&E-stained sections of immunohistochemical RCC xenografts obtained from animals in control and treatment groups. Magnification, ×40. Scale bars, 50 µm. T, tumor; He, hemorrhage. B, endpoint tumor weights; results for each treatment group represent mean ± SE (n = 3). C, biweekly serial caliper measurements. Tumor size was calculated by L × W. Each treatment group was normalized to pretreatment measurements and converted to percent tumor growth. Each point represents mean ± SE. *, combination compared with single treatments (ASA404, P= 0.03 and everolimus, P= 0.05).